An Optical Fiber-based SPR Sensor for Hepatocellular Carcinoma Detection

Renata Charlene Barbosa Xavier; Jessica Neiva Alpino; Cleumar da Silva Moreira; Rossana Moreno Santa Cruz

doi:10.20906/CBA2022/3398

Renata Charlene Barbosa Xavier Department of Electrical Engineering, Federal Institute of Paraíba, PB
Jessica Neiva Alpino Department of Electrical Engineering, Federal Institute of Paraíba, PB
Cleumar da Silva Moreira Department of Electrical Engineering, Federal Institute of Paraíba, PB
Rossana Moreno Santa Cruz Department of Electrical Engineering, Federal Institute of Paraíba, PB

DOI: https://doi.org/10.20906/CBA2022/3398

Keywords: Surface plasmon resonance, optical fiber sensor, hepatocellular carcinoma, ZBLAN, performance

Abstract

An optical fiber-based surface plasmon resonance sensor for hepatocellular carcinoma diagnosis is presented here. Conventional, tip-based, and D-shaped configurations are used to construct the sensor. The sensing region length, the bimetallic layer, full width at half maximum (FWHM), figure of merit (FOM), sensitivity, and signal-to-noise ratio (SNR) have been used to analyze the sensor performance. The sensor setup uses three layers: a ZBLAN fluoride optical fiber core (optical substrate), a 40 nm-gold or 40 nm-silver films (plasmonic metal), and healthy and pathological samples (analyte). Moreover, a bimetallic layer has been also investigated, where the thicknesses ranged from 10 nm to 40 nm. Also, the sensing region varied from 5 mm to 60 mm. The results obtained for the sensitivity of the simulated sensors were: 3, 903.4 nm/RIU for gold, 3, 821.5 nm/RIU for silver, and 3, 415.1 nm/RIU for silver-gold layer.